The Cell and Gene Therapy Catapult is developing new ways to examine how well gene modified T-cells can kill cancer cells. T-Cells, which form part of the human immune system and have the ability to kill tumour cells, are at the frontier of medical research in oncology.

By effectively ‘training’ T-Cells to recognise proteins which are expressed on the surface of certain types of blood cancer cells, they are able to recognise them and initiate a killing response.

This time-lapse video demonstrates the activity of gene-modified T-Cells, by recognising a specific protein called on leukaemia cells.

In the video, the engineered T-Cells have been stained with a fluorescent dye and appear blue. The cancer cells expressing the protein are dyed green. Once the cancer cells have been killed they change colour and appear red.